<i>In Silico</i>, <i>In Vitro</i>, and <i>In Vivo</i> Evaluation of Precipitation Inhibitors in Supersaturated Lipid-Based Formulations of Venetoclax
Niklas J. Koehl, Laura J. Henze, Harriet Bennett-Lenane, Waleed Faisal, Daniel J. Price, René Holm, Martin Kuentz, Brendan T. Griffin
Abstract
exposure of venetoclax was achieved using a sLBF approach, and despite the perceived risk of drug precipitation from a sLBF, including a PI may not be merited in all cases.
Topics & Concepts
In silicoIn vivoVenetoclaxIn vitroChemistryComputational biologyPharmacologyBiochemistryMedicineBiologyInternal medicineGeneticsChronic lymphocytic leukemiaGeneLeukemiaDrug Solubulity and Delivery SystemsNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems