Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus
Dereje A. Negatu, Andreas Beuchel, Abdeldjalil Madani, Nadine Álvarez, Chao Chen, Wassihun Wedajo Aragaw, Matthew Zimmerman, Benoı̂t Laleu, Martin Gengenbacher, Véronique Dartois, Peter Imming, Thomas Dick
Abstract
New, more-effective drugs for the treatment of lung disease caused by nontuberculous mycobacteria (NTM) are needed. Among NTM opportunistic pathogens, Mycobacterium abscessus is the most difficult to cure and intrinsically multidrug resistant. In a whole-cell screen of a compound collection active against Mycobacterium tuberculosis , we previously identified the piperidine-4-carboxamide (P4C) MMV688844 (844) as a hit against M. abscessus .
Topics & Concepts
DNA gyraseMycobacterium abscessusPiperidineMicrobiologyDNAMycobacteriumBiologyBacteriaEscherichia coliGeneticsChemistryStereochemistryGeneMycobacterium research and diagnosisInfectious Diseases and MycologyTuberculosis Research and Epidemiology