Immune modulation after traumatic brain injury
Marwan Bouras, Karim Asehnoune, Antoine Roquilly
Abstract
Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue, followed by a systematization of the inflammatory response. The subsequent response, evolved to limit an overwhelming systemic inflammatory response and to induce healing, involves the autonomic nervous system, hormonal systems, and the regulation of immune cells. This physiological response induces an immunosuppression and tolerance state that promotes to the occurrence of secondary infections. This review describes the immunological consequences of TBI and highlights potential novel therapeutic approaches using immune modulation to restore homeostasis between the nervous system and innate immunity.
Topics & Concepts
Traumatic brain injuryImmune systemInnate immune systemNeuroscienceImmunosuppressionHomeostasisImmunityMedicineImmunologyInflammationCentral nervous systemBiologyInternal medicinePsychiatryTraumatic Brain Injury and Neurovascular DisturbancesRespiratory Support and MechanismsThermal Regulation in Medicine