Low-intensity pulsed ultrasound-generated singlet oxygen induces telomere damage leading to glioma stem cell awakening from quiescence
Sirong Song, Dongbin Ma, Lixia Xu, Qiong Wang, Lanxiang Liu, Xiaoguang Tong, Hua Yan
Abstract
results confirmed that LIPUS enhanced the GSC sensitivity to temozolomide. These results demonstrated that LIPUS "waked up" GSCs to improve their sensitivity to chemotherapy, and importantly, we confirmed the direct targeted proteins of LIPUS in GSCs.
Topics & Concepts
Stem cellLow-intensity pulsed ultrasoundTelomereInduced pluripotent stem cellTelomeraseChemistryCancer researchTemozolomideGliomaIn vivoCell biologyWnt signaling pathwayBiophysicsBiologyMedicineUltrasoundBiochemistrySignal transductionTherapeutic ultrasoundDNAEmbryonic stem cellGeneticsRadiologyGeneUltrasound and Hyperthermia ApplicationsPlanarian Biology and Electrostimulation3D Printing in Biomedical Research