Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy
Weisi Lu, Yunling Xie, Binjie Huang, Tenghui Ma, Huaiming Wang, Boxiong Deng, Shaomin Zou, Wencong Wang, Qin Tang, Ziqing Yang, Xuri Li, Lei Wang, Lekun Fang
Abstract
in mice ameliorated RP-induced injuries. Genome-wide gene expression profiling and in vitro assays revealed that the promotive effect of PDGF-C in RP development was mediated by activation of PDGF receptors (PDGFRs) and C-X-C motif chemokine receptor 4, a proinflammatory chemokine regulated by transcription factor ETS variant transcription factor 1. Treatment with crenolanib, a selective inhibitor of PDGFRs, prevented or reduced RP in mice after irradiation. These results reveal that inhibition of PDGF-C signaling may have therapeutic value for the treatment of RP.
Topics & Concepts
Platelet-derived growth factor receptorChemokineCancer researchProinflammatory cytokineTranscription factorFibrosisGrowth factorPlatelet-derived growth factorBiologyReceptorInflammationPharmacologyImmunologyMedicineInternal medicineGeneBiochemistryEffects of Radiation ExposureHepatocellular Carcinoma Treatment and PrognosisColorectal Cancer Surgical Treatments