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Simulation of the Pharmacokinetics of Oseltamivir and Its Active Metabolite in Normal Populations and Patients with Hepatic Cirrhosis Using Physiologically Based Pharmacokinetic Modeling

Yong Chen, Ke Meng, Jianwen Xu, Cuihong Lin

2020AAPS PharmSciTech20 citationsDOI

Topics & Concepts

PharmacokineticsPhysiologically based pharmacokinetic modellingOseltamivirNeuraminidase inhibitorCmaxPharmacologyActive metaboliteMetaboliteCirrhosisMedicineProdrugAdverse effectInternal medicineCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)DiseaseInfluenza Virus Research StudiesReceptor Mechanisms and SignalingAntibiotics Pharmacokinetics and Efficacy
Simulation of the Pharmacokinetics of Oseltamivir and Its Active Metabolite in Normal Populations and Patients with Hepatic Cirrhosis Using Physiologically Based Pharmacokinetic Modeling | Litcius