Asymmetric catalytic Friedel–Crafts alkylation with arenes and heteroarenes: construction of 3,3-disubstituted oxindoles
Tinghui Zhang, Ziwei Zhong, Zi Zeng, Zitong Zhu, Fei Wang, Yuxin Zhang, Xiaohua Liu, Maoping Pu, Xiaoming Feng
Abstract
The asymmetric Friedel–Crafts alkylation of 3-bromo-3-substituted oxindoles with arenes and heteroarenes was achieved to synthesize enantioenriched C3-arylated oxindoles.
Topics & Concepts
Friedel–Crafts reactionChemistryAlkylationCatalysisOrganic chemistryCombinatorial chemistryAsymmetric Synthesis and CatalysisAxial and Atropisomeric Chirality SynthesisSynthetic Organic Chemistry Methods