Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 <sup>+</sup> T cell clone size and cytotoxicity
Robert Watson, Orion Tong, Rosalin Cooper, Chelsea Taylor, Piyush Kumar Sharma, Alba Verge de los Aires, Elise A. Mahé, Hélène Ruffieux, Isar Nassiri, Mark R. Middleton, Benjamin P. Fairfax
Abstract
The cytotoxicity and clone size of CD8 + T cell pretreatment are prognostic for immune checkpoint blockade.
Topics & Concepts
CD8BiologyCytotoxic T cellImmune systemImmune checkpointclone (Java method)T cellEffectorT-cell receptorImmunologyCancer researchImmunotherapyGeneGeneticsIn vitroCancer Immunotherapy and BiomarkersCAR-T cell therapy researchImmune Cell Function and Interaction