Epigallocatechin Gallate Protects Mice against Methionine–Choline-Deficient-Diet-Induced Nonalcoholic Steatohepatitis by Improving Gut Microbiota To Attenuate Hepatic Injury and Regulate Metabolism
Kaiting Ning, Kaikai Lu, Qian Chen, Zizhen Guo, Xiaojuan Du, Farooq Riaz, Lina Feng, Yuping Fu, Chunyan Yin, Fujun Zhang, Litao Wu, Dongmin Li
Abstract
. Altogether, the salutary effect of EGCG on NASH might be via shifting gut flora and certain enzymes from genera. Our study thus takes a step toward NASH prevention and therapy.
Topics & Concepts
Nonalcoholic steatohepatitisCholineMethionineGallateMetabolismLipid metabolismGut floraSteatohepatitisChemistryEpigallocatechin gallateMedicineInternal medicineNonalcoholic fatty liver diseaseBiochemistryPharmacologyFatty liverAntioxidantDiseasePolyphenolAmino acidTea Polyphenols and EffectsDiet and metabolism studiesTryptophan and brain disorders