12‐Tungstosilicic Acid H <sub>4</sub> [W <sub>12</sub> SiO <sub>40</sub> ] Over Natural Bentonite as a Heterogeneous Catalyst for the Synthesis of 3,4‐dihydropyrimidin‐2(1H)‐Ones
Lakha V. Chopda, Pragnesh N. Dave
Abstract
Abstract Regionally available bentonite was modified by using heteropolyacid 12‐tungstosilicic acid H 4 [W 12 SiO 40 ] (TSA). The prepared 10–30 % TSA/bent catalysts were characterized by XRD, FTIR, FeSEM and EDS. The catalytic activity of all three samples was studied on classical Biginelli reaction. Among all, 30 % TSA/bent displayed high catalytic activity and reusability. The effect of solvent was also undertaken to find the best media for the reaction. This protocol was extended to various aldehydes for the synthesis of different dihydropyrimidones (DHPMs) in high yields in ethanol.
Topics & Concepts
CatalysisBentoniteChemistryFourier transform infrared spectroscopyReusabilityNuclear chemistryEthanolBiginelli reactionSolventHeterogeneous catalysisOrganic chemistryChemical engineeringComputer scienceSoftwareEngineeringProgramming languageMulticomponent Synthesis of HeterocyclesSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activity