Identification of human immune cell subtypes most responsive to IL-1β–induced inflammatory signaling using mass cytometry
Hema Kothari, Corey M. Williams, Chantel McSkimming, Fabrizio Drago, Melissa A. Marshall, James C. Garmey, Mythili Vigneshwar, Eli R. Zunder, Coleen A. McNamara
Abstract
T cell subtypes could identify those patients at higher risk of cytokine storm and most likely to benefit from IL-1β-neutralizing therapies.
Topics & Concepts
Mass cytometryImmune systemFlow cytometryImmunologyBiologyInflammationIdentification (biology)Signal transductionCell biologyPhenotypeGeneGeneticsBotanyIL-33, ST2, and ILC PathwaysAtherosclerosis and Cardiovascular DiseasesImmune Cell Function and Interaction