Virtual Screening: Is Bigger Always Better? Or Can Small Be Beautiful?
David E. Clark
Abstract
This viewpoint is intended to counterbalance some recent publications describing large-scale virtual screening by illustrating how success in launching drug discovery projects has been achieved with much more modest resources. Two examples of small-scale virtual screening that led to the discovery of clinical candidates are cited in favor of this argument.
Topics & Concepts
Virtual screeningArgument (complex analysis)Drug discoveryData scienceScale (ratio)Computer scienceMedicineBioinformaticsGeographyBiologyCartographyInternal medicineGenetics, Bioinformatics, and Biomedical ResearchComputational Drug Discovery MethodsBiotechnology and Related Fields