Amelioration of diet-induced hyperglycemia by wheat peptides in a multi-target manner: integrated modulation of inflammation, lipid metabolism, gut microbiota, and DPP-IV inhibition
Fei Shen, Qian Deng, Yishan Song, Guanghua He, Xiaojun Chu, Minjie Zhao, Juan Du, Fengqin Feng, Xi Zhang, Hao Zhong
Abstract
) normalized glycemic levels. Collectively, WP exerts hypoglycemic effects through potentially synergistic mechanisms: (i) suppression of inflammation, (ii) restoration of functional lipid and tryptophan metabolic pathways, (iii) modulation of the gut microbiota toward a beneficial profile, and (iv) DPP-IV inhibition by structurally optimized peptides. These findings highlight WP's therapeutic potential for metabolic syndrome, underscoring its utility as a multifaceted intervention for metabolic dysregulation.
Topics & Concepts
ChemistryGut floraEndocrinologyInternal medicineMetaboliteTryptophanBiochemistryGlucose homeostasisLipid metabolismAdipocyteCholesterolLipoproteinCarbohydrate metabolismInflammationInsulinGlucagon-like peptide-1Energy homeostasisNEFAHomeostasisPharmacologyMetabolismHyperlipidemiaLipopolysaccharideDiet-induced obeseDiabetes mellitusMetabolic syndromeSerum amyloid ALipolysisInsulin resistanceTyrosineMetabolic pathwayCurcuminHormoneTriglycerideOxidative stressProtein Hydrolysis and Bioactive PeptidesGABA and Rice ResearchAntimicrobial Peptides and Activities