Dipeptide Mimetics of Different NGF and BDNF Loops Activate PLC-γ1
Т. А. Гудашева, И. О. Логвинов, С. В. Николаев, Т. А. Антипова, P. Yu. Povarnina, С. Б. Середенин
Abstract
Previously, we designed and synthesized dipeptide mimetics of individual loops of the nerve growth factor (NGF) and the brain-derived neurotrophic factor (BDNF). It was shown that these mimetics activate the corresponding tyrosine kinase (Trk) receptors and have different patterns of activation of the PI3K/AKT and MAPK/ERK postreceptor signaling pathways in vitro. In the present study, it was shown on HT-22 cells that all these compounds activate the phospholipase C-γ1 (PLC-γ1) cascade.
Topics & Concepts
Trk receptorDipeptideMAPK/ERK pathwayNeurotrophinPhospholipase CNerve growth factorChemistryBrain-derived neurotrophic factorCell biologyNeurotrophic factorsProtein kinase BReceptor tyrosine kinaseSignal transductionReceptorBiochemistryBiologyPeptideNerve injury and regenerationAxon Guidance and Neuronal SignalingNuclear Receptors and Signaling