Angiogenin promotes angiogenesis via the endonucleolytic decay of miR-141 in colorectal cancer
Chunhua Weng, Haojie Dong, Rongpan Bai, Jinghao Sheng, Guangdi Chen, Kefeng Ding, Weiqiang Lin, Jianghua Chen, Zhengping Xu
Abstract
inhibits ANG-mediated miR-141 decay, thus decreasing the angiogenesis process of HUVECs. We also find an inverse correlation between ANG and miR-141 expression in colorectal cancer (CRC) tissues. Our study indicates that ANG regulates CRC progression by disrupting miR-141 and its regulation on angiogenesis-related target genes, not only revealing a new mechanism of ANG action but also newly identifying miR-141 as a substrate of ANG. This study suggests that targeting ANG nuclease activity might be valuable in treating angiogenesis-related diseases through coordinately regulating the metabolism of rRNA, tiRNA, and miRNA.