Diabetic Ketoacidosis on Hospitalization with COVID-19 in a Previously Nondiabetic Patient: A Review of Pathophysiology
Rawan Eskandarani, Shaima Sawan
Abstract
Hyperglycaemia during inpatient admission is indicative of higher morbidity and mortality risks in critically ill patients. The severe acute respiratory distress coronavirus 2 (SARS-CoV-2) has been reported to induce ketoacidosis and diabetic ketoacidosis (DKA) even in nondiabetic patients. The pathophysiology of the SARS-CoV-2 infection that can contribute to hyperglycaemia, and the exacerbated inflammatory cytokine storm can overlap with the metabolic chronic inflammatory state attributable to the metabolic syndrome, which underlies diabetes mellitus. In this report, we explore the possible pathophysiology and metabolic mechanisms that lead to metabolic acidosis in nondiabetic patients.
Topics & Concepts
MedicinePathophysiologyDiabetic ketoacidosisDiabetes mellitusCytokine stormRespiratory distressMetabolic acidosisIntensive care medicineKetoacidosisMetabolic disorderCoronavirus disease 2019 (COVID-19)Internal medicineType 1 diabetesEndocrinologyDiseaseSurgeryInfectious disease (medical specialty)Diabetes and associated disordersDiet and metabolism studiesCOVID-19 Clinical Research Studies