Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
Kateřina Sobolová, Martina Hrabinová, Vendula Hepnarová, Tomáš Kučera, Tereza Kobrlová, Markéta Benková, Jana Janočková, Rafael Doležal, Lukáš Prchal, Ondřej Benek, Eva Mezeiová, Daniel Jun, Ondřej Soukup, Jan Korábečný
Topics & Concepts
BerberineOligopeptidaseChemistryButyrylcholinesteraseAcetylcholinesteraseStereochemistryDocking (animal)CytotoxicityIn vitroAchéEnzymeBiochemistryNursingMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsBerberine and alkaloids research