Design, synthesis, and <i>in vitro</i> and <i>in silico</i> study of 1-benzyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors
Zahra Batool, Naeem Ullah, Ajmal Khan, Farhan Siddique, Sumaira Nadeem, Abdulrahman Alshammari, Norah A. Albekairi, Rimsha Talib, Ahmed Al‐Harrasi, Zahid Shafiq
Abstract
analysis (including ADMET prediction and molecular docking) was conducted and compared with the standard drug (kojic acid). These findings may help the hunt for new melanogenesis inhibitors that the food and cosmetics industries may find valuable.
Topics & Concepts
In silicoIndole testTyrosinaseChemistryIn vitroCombinatorial chemistryStereochemistryBiochemistryEnzymeGenemelanin and skin pigmentationBioactive Compounds and Antitumor AgentsPhotochromic and Fluorescence Chemistry