Curcumin alleviates hepatic steatosis by improving mitochondrial function in postnatal overfed rats and fatty L02 cells through the SIRT3 pathway
Susu Du, Xiaolei Zhu, Nan Zhou, Wen Zheng, Wei Zhou, Xiaonan Li
Abstract
, L02 cells were exposed to free fatty acids and/or CUR. CUR decreased the levels of cellular lipids and mitochondrial reactive oxygen species, and increased the mitochondrial DNA copy number and superoxide dismutase activity in fatty L02 cells. However, these effects were blocked after SIRT3 silencing. It was concluded that postnatal overfeeding damaged mitochondrial biogenesis and antioxidant response, and increased hepatic lipids and the severity of high-fat-induced NAFLD, while CUR alleviated hepatic steatosis, at least partially, by enhancing mitochondrial function through SIRT3.
Topics & Concepts
SteatosisInternal medicineEndocrinologySIRT3Fatty liverBiologyMitochondrionCurcuminChemistryMedicineBiochemistryGeneDiseaseSirtuinAcetylationLiver Disease Diagnosis and TreatmentBiochemical effects in animalsCurcumin's Biomedical Applications