Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels
Sian O' Brien, Andrew P. Holmes, Daniel M. Johnson, S. Nashitha Kabir, Christopher O' Shea, Molly O' Reilly, Adelisa Avezzù, Jasmeet S. Reyat, Amelia Weber Hall, Clara Apicella, Patrick T. Ellinor, Steven Niederer, Nathan R. Tucker, Larissa Fabritz, Paulus Kirchhof, Davor Pavlović
Abstract
, greater reduction of maximum upstroke velocity of action potential, and slowed conduction in atrial cells and tissue. Our work highlights differences in biophysical properties of sodium channels in left atria and ventricles and their response to flecainide. These differences can explain the relative safety of sodium channel blocker therapy in patients with atrial fibrillation.
Topics & Concepts
FlecainideAtrial fibrillationCardiologySodium channelInternal medicineVentricleSodium channel blockerMedicineNerve conduction velocityAtrial action potentialPopulationSodiumElectrophysiologyChemistryRepolarizationOrganic chemistryEnvironmental healthCardiac electrophysiology and arrhythmiasAtrial Fibrillation Management and OutcomesCardiac Arrhythmias and Treatments