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Discovery of L15 as a novel Vif PROTAC degrader with antiviral activity against HIV-1

Dan Luo, Rong‐Hua Luo, Weilin Wang, Rui Deng, Shirui Wang, Xinyu Ma, Chunlan Pu, Yuanyuan Liu, Hongjia Zhang, Su Yu, Qing Huang, Liu‐Meng Yang, Yu Tong, Yong‐Tang Zheng, Rui Li

2024Bioorganic & Medicinal Chemistry Letters15 citationsDOI

Topics & Concepts

ChemistryHuman immunodeficiency virus (HIV)Drug discoveryLentivirusVirologyPharmacologyStereochemistryBiochemistryViral diseaseBiologyMedicineProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis
Discovery of L15 as a novel Vif PROTAC degrader with antiviral activity against HIV-1 | Litcius