Rational design of iridium–porphyrin conjugates for novel synergistic photodynamic and photothermal therapy anticancer agents
Liping Zhang, Yun Geng, Lijuan Li, Xiaofan Tong, Shi Liu, Xingman Liu, Zhongmin Su, Zhigang Xie, Dongxia Zhu, Martin R. Bryce
Abstract
Iridium–porphyrin conjugates assembled in nanoparticles are photosensitizers that exhibit excellent photothermal imaging and synergistic PDT and PTT in vivo .
Topics & Concepts
Photodynamic therapyPhotothermal therapyPorphyrinIridiumRational designConjugateCombinatorial chemistryCancer therapyChemistryNanotechnologyMaterials scienceCancerPhotochemistryOrganic chemistryMedicineMathematicsCatalysisInternal medicineMathematical analysisNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies