Flash nanoprecipitation assisted self-assembly of ionizable lipid nanoparticles for nucleic acid delivery
Bishal Misra, Krystal A. Hughes, William H. Pentz, Parinya Samart, Werner J. Geldenhuys, Sharan Bobbala
Abstract
, whereas Dlin-MC3-DMA LNPs allowed effective intracellular siRNA delivery with great functional ability. The FNP technique could economically produce LNPs in smaller volumes that are highly suitable for the discovery phase.
Topics & Concepts
Nucleic acidFlash (photography)NanoparticleNanotechnologySolid lipid nanoparticleChemistryMaterials scienceCombinatorial chemistryBiochemistryPhysicsOpticsRNA Interference and Gene DeliveryLipid Membrane Structure and BehaviorMicrofluidic and Capillary Electrophoresis Applications