DNA compaction and dynamic observation in a nanopore gated sub-attoliter silicon nanocavity
Shuangshuang Zeng, Mauro Chinappi, Fabio Cecconi, Theo Odijk, Zhen Zhang
Abstract
ionic current measurements. The mechanism for the DNA compaction is elucidated by varying the DNA length or concentration, voltage polarity, nanocavity dimensions and ionic strength. Furthermore, Brownian dynamics simulations reveal the dynamic fluctuations of the compacted DNA, which are reflected in the measured ionic current. Our nanocavity device is anticipated to provide a controlled environment in extremely small volumes for investigating the physics of confined biopolymers.
Topics & Concepts
NanoporeMaterials scienceNanoscopic scaleNanotechnologyDNAIonic bondingSiliconChemical physicsDNA nanotechnologyOptoelectronicsChemistryIonBiochemistryOrganic chemistryNanopore and Nanochannel Transport StudiesMicrofluidic and Capillary Electrophoresis ApplicationsIon-surface interactions and analysis