Chemical Control of Quorum Sensing in <i>E. coli</i>: Identification of Small Molecule Modulators of SdiA and Mechanistic Characterization of a Covalent Inhibitor
Matthew J. Styles, Stephen A. Early, Trisha Tucholski, Korbin H. J. West, Ying Ge, Helen E. Blackwell
Abstract
modulators could be used to advance the study of LuxR-type receptor/ligand interactions, the biological roles of orphan LuxR-type receptors, and potential QS-based therapeutic approaches.
Topics & Concepts
Quorum sensingVirulenceBiologyEscherichia coliMicrobiologyBiofilmHomoserineReceptorBacteriaPhenotypeComputational biologyBiochemistryGeneticsGeneEscherichia coli research studiesAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensing