Ketamine Metabolite (2<i>R</i>,6<i>R</i>)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors
Thomas T. Joseph, Weiming Bu, Wen‐Zhen Lin, Lioudmila Zoubak, Alexei Yeliseev, Renyu Liu, Roderic G. Eckenhoff, Grace Brannigan
Abstract
values congruous with our simulations. Overall, our findings are consistent with opioid pathway involvement in ketamine function.
Topics & Concepts
NaltrexoneKetaminePharmacologyOpioidOpioid receptorReceptorChemistryMetaboliteAnalgesicInverse agonistAntidepressantAgonistMedicineBiologyInternal medicineBiochemistryNeuroscienceHippocampusReceptor Mechanisms and SignalingTryptophan and brain disordersTreatment of Major Depression