Genetic retargeting of E3 ligases to enhance CAR T cell therapy
Isabel C. Lane, Gabriele Kembuan, Jeannie Carreiro, Michael C. Kann, William M. Lin, Amanda A. Bouffard, Johannes Kreuzer, Robert Morris, Emily M. Schneider, Joanna Y. Kim, Charles Zou, Diego Salas‐Benito, Jessica A. Gasser, Mark B. Leick, Mikołaj Słabicki, Wilhelm Haas, Marcela V. Maus, Max Jan
Topics & Concepts
Ubiquitin ligaseUbiquitinSMADFusion proteinChimeric antigen receptorBiologyCancer researchProtein degradationCell biologyCancerSignal transductionRecombinant DNAImmunotherapyBiochemistryGeneticsGeneCAR-T cell therapy researchProtein Degradation and InhibitorsCRISPR and Genetic Engineering