Increased Listeria monocytogenes Dissemination and Altered Population Dynamics in Muc2-Deficient Mice
Ting Zhang, Jumpei Sasabe, Karthik Hullahalli, Brandon Sit, Matthew K. Waldor
Abstract
The mucin Muc2 is a major constituent of the mucus layer that covers the intestinal epithelium and creates a barrier between epithelial cells and luminal commensal or pathogenic microorganisms. The Gram-positive foodborne pathogen Listeria monocytogenes can cause enteritis and also disseminate from the intestine to give rise to systemic disease. L. monocytogenes can bind to intestinal Muc2, but the influence of the Muc2 mucin barrier on L. monocytogenes intestinal colonization and systemic dissemination has not been explored.
Topics & Concepts
Listeria monocytogenesBiologyMucinMucin 2MicrobiologyMucusPathogenIntestinal epitheliumListeriaPopulationEpitheliumBacteriaGeneMedicineGeneticsEcologyEnvironmental healthGene expressionBiochemistryProbiotics and Fermented FoodsListeria monocytogenes in Food SafetyMicrobial Inactivation Methods