Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice
Francesca Castoldi, Guido Kroemer, Federico Pietrocola
Abstract
. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.
Topics & Concepts
ImmunosurveillanceSpermidineImmunologyTumor immunologyMedicineCancer researchBiologyImmunotherapyTumor cellsImmune systemBiochemistryEnzymePolyamine Metabolism and ApplicationsHIV Research and TreatmentAntimicrobial Peptides and Activities