Effects of fecal microbiota transplant on DNA methylation in subjects with metabolic syndrome
Eduard W. J. van der Vossen, D. Bastos, Daniela Stols‐Gonçalves, Marcus C. de Goffau, Mark Davids, João Pereira, Andrew Y. F. Li Yim, Peter Henneman, Mihai G. Netea, Willem M. de Vos, Wouter de Jonge, Albert K. Groen, Max Nieuwdorp, Evgeni Levin
Abstract
ASVs directly correlated with methylation of AFAP1, a gene involved in mitochondrial function, insulin sensitivity, and peripheral insulin resistance (Rd, rate of glucose disappearance). FMT was found to have notable effects on the gut microbiome but also on the host plasma metabolome and the epigenome of immune cells providing new avenues of inquiry in the context of metabolic syndrome treatment for the manipulation of host physiology to achieve improved insulin sensitivity.
Topics & Concepts
MetabolomeBiologyEpigenomeMicrobiomeMetabolomicsDNA methylationEpigenomicsGut floraInsulin resistancePrevotellaTranscriptomeImmunologyInsulinBioinformaticsGeneticsEndocrinologyBacteriaGeneGene expressionGut microbiota and healthEpigenetics and DNA MethylationDiet and metabolism studies