Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation
Chunqi Liu, Liang Wang, Xiaocong Liu, Yuping Tan, Lei Tao, Yuzhou Xiao, Pengchi Deng, Huijuan Wang, Qianyi Deng, Yiyun Lin, Hui Jie, Huaqin Zhang, Jing Zhang, Yong Peng, Hu Zhang, Zong‐Guang Zhou, Qingxiang Sun, Xiaobo Cen, Yinglan Zhao
Abstract
Taken together, our findings reveal a novel nonmetabolic function of SHMT2 in which it stabilizes β-catenin to prevent its ubiquitylation-mediated degradation and provide a potential therapeutic strategy for CRC therapy.
Topics & Concepts
Colorectal cancerMetastasisCateninCancer researchCytoplasmBeta-cateninCancerMedicineWnt signaling pathwayInternal medicineBiologyChemistryCell biologySignal transductionUbiquitin and proteasome pathwaysCancer-related gene regulationPeptidase Inhibition and Analysis