p27 controls Ragulator and mTOR activity in amino acid-deprived cells to regulate the autophagy–lysosomal pathway and coordinate cell cycle and cell growth
Ada Nowosad, Pauline Jeannot, Caroline Callot, Justine Creff, Renaud T. Perchey, Carine Joffre, Patrice Codogno, Stéphane Manenti, Arnaud Besson
Topics & Concepts
AutophagymTORC1Cell biologyLysosomePI3K/AKT/mTOR pathwayTFEBBAG3Mechanistic target of rapamycinCell cycleBiologyCell growthCellChemistrySignal transductionApoptosisBiochemistryEnzymeAutophagy in Disease and TherapyCancer-related Molecular PathwaysPolyamine Metabolism and Applications