Adoptive Transfer of Group 3-Like Innate Lymphoid Cells Restores Mouse Colon Resistance to Colonization of a Gamma Interferon-Susceptible Chlamydia muridarum Mutant
Ying He, Hong Xu, Chenchen Song, John J. Koprivsek, Bernard P. Arulanandam, Huixiang Yang, Lijian Tao, Guangming Zhong
Abstract
The obligate intracellular bacterium Chlamydia muridarum can colonize the mouse colon for a long period, but a gamma interferon (IFN-γ)-susceptible mutant clone fails to do so. Nevertheless, the mutant’s colonization is rescued in mice deficient in interleukin-7 receptor (IL-7R) (lacking both lymphocytes and innate lymphoid cells [ILCs]) or IFN-γ but not in mice lacking recombination-activated gene 1 (Rag1 −/− mice) (lacking adaptive immunity lymphocytes), indicating a critical role of ILC-derived IFN-γ in regulating chlamydial colonization.
Topics & Concepts
BiologyMutantAdoptive cell transferInnate lymphoid cellChlamydia trachomatisInterferon gammaRecombination-activating geneInterferonImmunityColonizationclone (Java method)ChlamydiaObligateInnate immune systemIntracellular parasiteImmunologyMicrobiologyVirologyCytokineGeneImmune systemGeneticsT cellRecombinationEcologyIL-33, ST2, and ILC PathwaysImmune Cell Function and InteractionReproductive System and Pregnancy