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Discovery of KRas G12C-IN-3 and Pomalidomide-based PROTACs as degraders of endogenous KRAS G12C with potent anticancer activity

Ling Li, Yinrong Wu, Zichao Yang, Chenglong Xu, Huiting Zhao, Jin Liu, Jingxuan Chen, Jingxuan Chen, Jianjun Chen, Jianjun Chen

2021Bioorganic Chemistry40 citationsDOI

Topics & Concepts

KRASChemistryCancer researchPharmacologyBiochemistryMutationBiologyGeneProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways
Discovery of KRas G12C-IN-3 and Pomalidomide-based PROTACs as degraders of endogenous KRAS G12C with potent anticancer activity | Litcius