BIRC7 promotes epithelial-mesenchymal transition and metastasis in papillary thyroid carcinoma through restraining autophagy.
Kunpeng Liu, Qingan Yu, Hao Li, Changming Xie, Yaohua Wu, Dakun Ma, Ping Sheng, Wenjie Dai, Hongchi Jiang
Abstract
. These findings indicate that the suppression of autophagy by BIRC7 drives the invasion and metastasis of PTC cells, thus suggesting that the activation of autophagy may inhibit metastasis of PTC with high BIRC7 expression.
Topics & Concepts
Cancer researchBECN1MetastasisEpithelial–mesenchymal transitionGene knockdownThyroid carcinomaAutophagyPathologyBiologyThyroid cancerCancerCell migrationApoptosisCell cultureMedicineThyroidInternal medicineEndocrinologyBiochemistryGeneticsCancer-related Molecular PathwaysHippo pathway signaling and YAP/TAZCell death mechanisms and regulation