Photodriven Radical Perfluoroalkylation–Thiolation of Unactivated Alkenes Enabled by Electron Donor–Acceptor Complex
Lixin Liu, Qian Wang, Yuanhua Li, Min Liu, Bifu Liu, Qiang Li, Kejun Feng
Abstract
A clean and direct three-component radical 1,2-difunctionalization of various alkenes with perfluoroalkyl iodides and thiosulfonates enabled by the electron donor–acceptor complex has been developed under light illumination at room temperature. The approach offers a convenient and environmentally friendly route for the simultaneous incorporation of Csp 3 –R f and Csp 3 –S bonds, affording valuable polyfunctionalized alkane derivatives containing fluorine and sulfur in satisfactory yields. Consequently, this methodology holds significant value and practicality in the field of organic synthesis.
Topics & Concepts
ChemistryEnvironmentally friendlyAlkaneElectron donorAcceptorElectron acceptorPhotochemistryCombinatorial chemistrySulfurAlkeneOrganic chemistryHydrocarbonCatalysisCondensed matter physicsBiologyPhysicsEcologyFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesRadical Photochemical Reactions