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A CD25×TIGIT bispecific antibody induces anti-tumor activity through selective intratumoral Treg cell depletion

Xin Wei, Linlin Zhao, Fang Yang, Yajing Yang, Huixiang Zhang, Kaixin Du, Xinxin Tian, Ruihua Fan, Guangxu Si, Kailun Wang, Yulu Li, Zhizhong Wei, Miaomiao He, Jianhua Sui

2024Molecular Therapy13 citationsDOIOpen Access PDF

Topics & Concepts

TIGITMonoclonal antibodyEffectorIL-2 receptorAntibodyTreg cellCancer researchRegulatory T cellImmunologyT cellBiologyChemistryImmune systemCAR-T cell therapy researchT-cell and B-cell ImmunologyImmunotherapy and Immune Responses
A CD25×TIGIT bispecific antibody induces anti-tumor activity through selective intratumoral Treg cell depletion | Litcius