Synthesis and Cytotoxicity of Chalcone Based 1,2,3-Triazole Derivatives
M. Raghavender, A. Kishore Kumar, V. Sunitha, T. Vishnu, P. Jalapathi
Abstract
Abstract Synthesis of a novel series of chalcone based 1,2,3-triazole derivatives and their anti-cancer studies are presented. Majority of the target compounds exhibit moderate to excellent activity against A-549 cells. Among the compounds screened 7c and 7j demonstrate potent activity being compared with the standard drug Doxorubicin.
Topics & Concepts
ChalconeChemistryCytotoxicityTriazoleDoxorubicinCombinatorial chemistry1,2,4-TriazoleStereochemistryIn vitroOrganic chemistryBiochemistryChemotherapySurgeryMedicineClick Chemistry and ApplicationsSynthesis and biological activitySynthesis and Biological Evaluation