Fabrication of nanoparticles with precisely controllable plasmonic properties as tools for biomedical applications
Pauline Kolar-Hofer, Giulia Zampini, Christian G. Derntl, Enrica Soprano, Ester Polo, Pablo del Pino, Nurgul Kereyeva, Moritz Eggeling, Leoni Breth, Michael J. Haslinger, M. Mühlberger, Peter Ertl, Astrit Shoshi, J. Hartbaum, Michael Jurisch, Beatriz Pelaz, Stefan Schrittwieser
Abstract
endocytosis, exhibit good biocompatibility, and show minor cytotoxicity, as evidenced by high cell viability. In the future, our high-precision nanoparticle fabrication method together with tunable surface plasmon resonance and reduced nanotoxicity will offer the possibility to replace conventional nanomaterials for biomedical applications that make use of an optical response at precise wavelengths. This includes the use of the nanoparticles as contrast agents for imaging, as probes for targeted photothermal cancer therapy, as carriers for controlled drug delivery, or as probes for sensing applications based on optical detection principles.