Using a Stationary Phase Based on Porous Graphitized Carbon for the Determination of 1,1-Dimethylhydrazine Transformation Products by Liquid Chromatography–Mass Spectrometry
N. V. Ul’yanovskii, Dmitry S. Kosyakov, Mark S. Popov, Ilya I. Pikovskoi, O. Yu. Khoroshev
Abstract
An approach to the simultaneous determination of five products of the transformation of rocket fuel on the basis of 1,1-dimethylhydrazine (1-methyl-1H-1,2,4-triazole, N-nitrosodimethylamine, N,N-dimethylformamide, and formaldehyde and acetaldehyde dimethylhydrazones) is proposed based on a combination HPLC on porous graphitized carbon (Hypercarb) with mass spectrometry and tandem mass spectrometry detection. The limits of detection are 0.6–7 µg/L. It was found that the stationary phase based on porous graphitized carbon ensures the effective chromatographic retention and separation of nitrogen-containing products 1,1-dimethylhydrazine transformation products by a mixed mechanism, including both hydrophobic and induction interactions with the analytes. The absence of matrix effects in the analysis of natural waters and a methanol extract from peat bog soil was shown.