Redox-dependent internalization of the purinergic P2Y <sub>6</sub> receptor limits colitis progression
Kazuhiro Nishiyama, Akiyuki Nishimura, Kakeru Shimoda, Tomohiro Tanaka, Yuri Kato, Takahiro Shibata, Hiroshi Tanaka, Hitoshi Kurose, Yasu‐Taka Azuma, Hideshi Ihara, Yoshito Kumagai, Takaaki Akaike, Philip Eaton, Kôji Uchida, Motohiro Nishida
Abstract
Cysteine modification of the purinergic receptor P2Y 6 R promotes internalization and degradation and limits colitis progression.
Topics & Concepts
InternalizationG protein-coupled receptorCell biologyChemistryReceptorBiochemistryBiologyReceptor Mechanisms and SignalingAdenosine and Purinergic SignalingPharmacological Receptor Mechanisms and Effects