Fine Particulate Matter (PM2.5) and the Blood–Testis Barrier: An <i>in Vivo</i> and <i>in Vitro</i> Mechanistic Study
Shaokai Zheng, Nannan Zhao, Xiaojun Lin, Lianlian Jiang, Chong Qiu, Jinchen Jiang, Zhenhao Shu, Yingyun Qian, Bo Liang, Lianglin Qiu
Abstract
BACKGROUND: -induced testicular injury are still unexplored. OBJECTIVES: signaling pathway in this process. METHODS: on the mice testes. Related markers and genes related to the blood-testis barrier (BTB) and ferroptosis were measured by quantitative real-time polymerase chain reaction (qPCR), western blot, and immunofluorescence assay. siRNA transfection was used to evaluate the potential mechanism. RESULTS: signaling pathway in male reproductive dysfunction. CONCLUSIONS: exposure in mice may lead to testicular dysfunction through new pathways. https://doi.org/10.1289/EHP14447.
Topics & Concepts
ParticulatesIn vivoIn vitroChemistryEnvironmental chemistryBiophysicsBiologyBiochemistryGeneticsOrganic chemistryAir Quality and Health Impacts