Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock
Emeka B. Okeke, Cameron Louttit, Chris Fry, Alireza Hassani Najafabadi, Kai Han, Jean A. Nemzek, James J. Moon
Topics & Concepts
Neutrophil extracellular trapsNeutrophil elastaseProinflammatory cytokineElastaseIn vivoProteasesExtracellularSerine proteaseMyeloperoxidaseInflammationImmunologyPharmacologyChemistryCell biologyMedicineBiologyBiochemistryProteaseEnzymeBiotechnologyNeutrophil, Myeloperoxidase and Oxidative MechanismsCell Adhesion Molecules ResearchImmune cells in cancer