The Effect of β-Lactam Antibiotics on the Evolution of Ceftazidime/Avibactam and Cefiderocol Resistance in KPC-Producing Klebsiella pneumoniae
Ping Zhang, Huangdu Hu, Qiucheng Shi, Long Sun, Xueqing Wu, Xiaoting Hua, Alan McNally, Yan Jiang, Yunsong Yu, Xiaoxing Du
Abstract
In this study, we aimed to clarify the evolutionary trajectory of a Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) population during β-lactam antibiotic therapy. Five KPC-Kp isolates were collected from a single patient.
Topics & Concepts
Klebsiella pneumoniaeCeftazidime/avibactamCeftazidimeMicrobiologyAntibioticsKlebsiellaBeta-lactamBiologyEnterobacteriaceaePopulationPseudomonas aeruginosaAntibiotic resistanceMedicineBacteriaEscherichia coliGeneticsGeneEnvironmental healthAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyBacterial biofilms and quorum sensing