Impact of dipeptide on ADC physicochemical properties and efficacy identifies Ala–Ala as the optimal dipeptide
Lu Wang, Adrian D. Hobson, Julia Fitzgibbons, Axel Hernández, Ying Jia, Zhou Xu, Zhongyuan Wang, Yajie Yu, Xiang Li
Abstract
A glucocorticoid receptor modulator (GRM) was conjugated to a mouse anti-TNF antibody using various dipeptide linkers. Impact of dipeptide linkers on ADC physical properties, including solubility, hydrophobicity, and aggregation were evaluated.
Topics & Concepts
DipeptideLinkerIn silicoChemistryCombinatorial chemistryAmino acidConjugated systemOligopeptideStereochemistryBiophysicsPeptideBiochemistryOrganic chemistryPolymerBiologyComputer scienceGeneOperating systemReceptor Mechanisms and SignalingChemical Synthesis and AnalysisMonoclonal and Polyclonal Antibodies Research