Opposing retrograde and astrocyte-dependent endocannabinoid signaling mechanisms regulate lateral habenula synaptic transmission
Nathan D. Winters, Veronika Kondev, Niharika Loomba, Eric Delpire, Brad A. Grueter, Sachin Patel
Abstract
receptors on astrocytes. Moreover, simultaneous depression of GABA and potentiation of glutamate release increases the net excitation-inhibition ratio onto LHb neurons, suggesting a potential cellular mechanism by which cannabinoids may promote LHb activity and subsequent anxious- and depressive-like aversive states.
Topics & Concepts
GlutamatergicEndocannabinoid systemNeuroscienceNeurotransmissionLong-term potentiationExcitatory postsynaptic potentialGABAergicGlutamate receptorCannabinoid receptorInhibitory postsynaptic potential2-ArachidonoylglycerolBiologyReceptorAgonistBiochemistryCannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology ResearchSleep and Wakefulness Research