Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy
Jing You, Wei Yang, Ronggang Ma, Anjie Xia, Guo Zhang, Zhen Fang, Nihong Guo, Shengyong Yang, Linli Li
Topics & Concepts
hERGChemistryPhenothiazineIn vivoProgrammed cell deathIn vitroPharmacologyLead compoundToxicityStructure–activity relationshipApoptosisBiochemistryBiophysicsPotassium channelBiologyOrganic chemistryBiotechnologyFerroptosis and cancer prognosisDrug Transport and Resistance MechanismsMicroRNA in disease regulation