‘Sugarcoating’ 2-deoxyglucose: mechanisms that suppress its toxic effects
Martin C. Schmidt, Allyson F. O’Donnell
Abstract
Yeast and cancer cells are metabolically similar as they use fermentation of glucose as a primary means of generating energy. Reliance on glucose fermentation makes both of these cell types highly sensitive to the toxic glucose analog, 2-deoxyglucose. Here we review the cellular and metabolic pathways that play a role in 2-deoxyglucose sensitivity and discuss how the modifications to these pathways result in acquisition of 2-deoxyglucose resistance. Insights gained from genetic and proteomic studies in yeast provide new ideas for the design of combinatorial therapies for cancer treatment.
Topics & Concepts
DeoxyglucoseBiologyYeastFermentationSaccharomyces cerevisiaeComputational biologyCarbohydrate metabolismProteomicsCellular metabolismBiochemistryCell biologyBioinformaticsMetabolismGeneFungal and yeast genetics researchMetabolism, Diabetes, and CancerEnzyme Structure and Function