Liposome biodistribution mapping with <i>in vivo</i> X-ray fluorescence imaging
Giovanni Marco Saladino, Po‐Han Chao, Bertha Brodin, Shyh‐Dar Li, Hans M. Hertz
Abstract
biodistribution of Ru-Lipo in mice, enabling tumor detection and longitudinal studies with elemental specificity and resolution down to the sub-millimeter scale. Quantitative XRF computed tomography on extracted organs permits targeting efficiency evaluations. These findings highlight the promising role of XRF imaging in pharmacokinetic studies and theranostic applications for the rapid optimization of drug delivery and assessment of targeting efficiency.
Topics & Concepts
BiodistributionLiposomeIn vivoFluorescenceNanotechnologyMaterials scienceBiophysicsMedical physicsChemistryMedicineOpticsPhysicsBiologyBiotechnologyNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsCancer Research and Treatments