Exploring the metabolic biomarkers and pathway changes in crucian under carbonate alkalinity exposure using high-throughput metabolomics analysis based on UPLC-ESI-QTOF-MS
Yanchun Sun, Shicheng Han, Ming‐Zhu Yao, Hongbai Liu, Yumei Wang
Abstract
-ATPase. At low concentrations, CA can change the normal metabolism of fish in terms of changing the osmotic pressure regulation capacity, antioxidant capacity, ammonia metabolism and liver and kidney function to adapt to the CA exposure environment. As the concentration of CA increases, various metabolic processes in crucian are inhibited, causing chronic damage to the body. The results show that the metabolomic strategy is a potentially powerful tool for identifying the mechanisms in response to different environmental exposomes and offers precious information about the chronic response of fish to CA.
Topics & Concepts
ChemistryUrea cycleMetabolic pathwayMetabolomicsMetabolismAlkalinityBiochemistryChromatographyAmino acidArginineOrganic chemistryPhysiological and biochemical adaptationsAquaculture Nutrition and GrowthAquaculture disease management and microbiota